Endocrine Abstracts

Temozolomide, an alkylating agent used in malignant gliomas, has been recently used too in the treatment of aggressive pituitary tumors. To date, two cases of Nelson’s syndrome has successfully treated with 5 days of 28-day cycle, but the follow-up has been shorter than 12 months. We reported the third patient with Nelson’s syndrome treated with temozolomide, who after an initial goal response to three 300 mg 5 days of 28-day cycles shown a clinical and biochemical (...

It is now well known that peripheral nervous system (PNS) is able to synthesize neurosteroids and to convert them, or hormonal steroids coming from the periphery, in neuroactive steroids. Moreover, PNS possess both classical (e.g., progesterone receptor, PR, androgen receptor, AR) and non-classical (e.g., GABAA receptor) steroid receptors and consequently may represent a target for the action of neuroactive steroids. Our data have indicated that neuroactive steroids, like for ...

Igfbp5 is the most conserved of the six members of the Igfbp family, which orchestrate the actions of the insulin-like growth factors (IGFs) systemically via blood and locally within tissues. Igfbp5 is upregulated in key lineages during development (e.g. muscle) and pathologies (e.g. rhabdomyosarcoma).To highlight the range and extent of Igfbp5 actions in vivo, we generated novel lines of transgenic mice t...

Introduction: Thyroid cancer is the most common endocrine neoplasia, being its papirally version the most frequent. (90% of all differentiated thyroid neoplasms). It is usually multifocal and metastasizes normally to regional lymph nodes.Objectives: To describe the prevalence of thyroid cancer and its histopathological variants in the different regions of the province of Malaga.Material and methods: We performed a retrospective des...

Introduction: Severe diabetic ketoacidosis (S-DKA) is a life-threatening condition requiring immediate hospitalization and treatment. Although mostly associated with type one diabetic patients, it is also a common condition in type two diabetes mellitus (T2DM). Our objective was to determine the main clinical and metabolic alterations associated with S-DKA in T2DM patients.Methods: We retrospectively analyzed the medical records of 27 consecutive T2DM pa...